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中国生物工程杂志

China Biotechnology
China Biotechnology
China Biotechnology  2015, Vol. 35 Issue (5): 87-95    DOI: 10.13523/j.cb.20150513
    
Progress in Biosynthesis of Purine Nucleosides and Their Derivatives by Metabolic Engineering
WANG Yong-cheng1,2,3, CHEN Tao1,2,3, SHI Ting1,2,3, WANG Zhi-wen1,2,3, ZHAO Xue-ming1,2,3
1. School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, China;
2. Key Laboratory of Systems Bioengineering Ministry of Education, Tianjin 300072, China;
3. SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
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Abstract  

Purine nucleosides and their derivatives play an very important role in food and pharmaceutical industry. In recent years, they have gained further importance because of their beneficial effects, related to their antioxidant, neuroprotective and immunomodulatory properties. However, It is time consuming and low efficiency to get high-performing strains through mutation screening techniques. Moreover, some of these strains have disadvantage of genetic instability. With the better understanding of regulation mechanism of microorganism, metabolic engineering has been widely applied to improve the production of purine nucleoside products. In this article, the purine biosynthetic pathway and regulation mechanism are discussed, and progress in metabolic engineering of purine nucleosides and their derivatives is also reviewed. Meanwhile, the current problems and future research direction are proposed.

Key words： Purine nucleosides      Purine biosynthetic pathway      Regulation mechanism      Metabolic engineering     
Received: 28 January 2015      Published: 25 May 2015
ZTFLH:  Q815  
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Cite this article:

WANG Yong-cheng, CHEN Tao, SHI Ting, WANG Zhi-wen, ZHAO Xue-ming. Progress in Biosynthesis of Purine Nucleosides and Their Derivatives by Metabolic Engineering. China Biotechnology, 2015, 35(5): 87-95.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20150513     OR     https://manu60.magtech.com.cn/biotech/Y2015/V35/I5/87


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