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中国生物工程杂志

China Biotechnology
China Biotechnology  2015, Vol. 35 Issue (2): 84-91    DOI: 10.13523/j.cb.20150213
    
Progress on the Technique and its Application of Reverse Genetics for Coronaviruses
SHEN Liang, TAN Wen-jie
Biotech Center for Viral Disease Emergency, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China
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Abstract  

Coronaviruses (CoVs) are a large family of viruses which threaten the health of humans and many animal species. Even though CoVs have high host specificity, novel subtype of CoVs emerge constantly due to their wide rang hosts and their special gene replication and transcription mechanisms. Currently the priority is to strengthen the research in pathogenesis and transmission mechanisms, as well as to develop vaccine and antiviral drugs. Recently, the applications of reverse genetics(RV) open up a new way for research of genomic functions of CoVs and development of novel vaccines against CoVs. The progress and application of different RV platforms developed for CoVs were focused, and the prospective aspects in the application of RV for CoVs were also discussed.



Key wordsCoronaviruses      Reverse genetics      Application     
Received: 11 October 2014      Published: 25 February 2015
ZTFLH:  Q789  
Cite this article:

SHEN Liang, TAN Wen-jie. Progress on the Technique and its Application of Reverse Genetics for Coronaviruses. China Biotechnology, 2015, 35(2): 84-91.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20150213     OR     https://manu60.magtech.com.cn/biotech/Y2015/V35/I2/84


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