[1] Yao L H, Jiang Y M, Shi J, et al. Flavonoids in food and their health benefits. Plant Foods for Human Nutrition, 2004,59(3):113-122.
[2] Middleton E, Kandaswami C, Theoharides T C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacological Reviews, 2000,52(4):673-751.
[3] Rice-Evans C A, Miller N J, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radical Biology & Medicine, 1996,20(7):933-956.
[4] Mavel S, Dikic B, Palakas S, et al. Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1). Bioorganic & Medicinal Chemistry, 2006,14(5):1599-1607.
[5] Winkel-Shirley B. Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. Plant Physiology, 2001,126(2):485-493.
[6] Hwang E I, Kaneko M, Ohnishi Y, et al. Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster. Applied and Environmental Microbiology, 2003,69(5):2699-2706.
[7] Santos C N, Koffas M, Stephanopoulos G. Optimization of a heterologous pathway for the production of flavonoids from glucose. Metabolic Engineering, 2011,13(4):392-400.
[8] Jiang H, Morgan J A. Optimization of an in vivo plant P450 monooxygenase system in Saccharomyces cerevisiae. Biotechnology and Bioengineering, 2004,85(2):130-137.
[9] Yan Y, Kohli A, Koffas M A. Biosynthesis of natural flavanones in Saccharomyces cerevisiae. Applied and Environmental Microbiology, 2005,71(9):5610-5613.
[10] Koopman F, Beekwilder J, Crimi B, et al. De novo production of the flavonoid naringenin in engineered Saccharomyces cerevisiae. Microbial Cell Factories, 2012,11:155.
[11] Takamura Y, Nomura G. Changes in the intracellular concentration of acetyl-CoA and malonyl-CoA in relation to the carbon and energy metabolism of Escherichia coli K12. Journal of General Microbiology, 1988,134(8):2249-2253.
[12] Miyahisa I, Kaneko M, Funa N, et al. Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster. Applied Microbiology and Biotechnology, 2005,68(4):498-504.
[13] Leonard E, Lim K H, Saw P N, et al. Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli. Applied and Environmental Microbiology, 2007,73(12):3877-3886.
[14] Burgard A P, Pharkya P, Maranas C D. Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization. Biotechnology and Bioengineering, 2003,84(6):647-657.
[15] Tepper N, Shlomi T. Predicting metabolic engineering knockout strategies for chemical production: accounting for competing pathways. Bioinformatics, 2010,26(4):536-543.
[16] Fowler Z L, Gikandi W W, Koffas M A. Increased malonyl coenzyme A biosynthesis by tuning the Escherichia coli metabolic network and its application to flavanone production. Applied and Environmental Microbiology, 2009,75(18):5831-5839.
[17] Xu P, Ranganathan S, Fowler Z L, et al. Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA. Metabolic Engineering, 2011,13(5):578-587.
[18] Zhu S, Wu J, Du G, et al. Efficient synthesis of eriodictyol from L-tyrosine in Escherichia coli. Applied and Environmental Microbiology, 2014, doi:10.1128/AEM. 03986-13.
[19] Wu J, Du G, Zhou J, et al. Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy. Metabolic Engineering, 2013,16:48-55.
[20] Leonard E, Chemler J, Lim K H, et al. Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in Escherichia coli. Applied Microbiology and Biotechnology, 2006,70(1):85-91.
[21] Fotsis T, Pepper M, Adlercreutz H, et al. Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis. The Journal of Nutrition, 1995,125(3 Suppl):790S-797S.
[22] 陈尚武,郝佳, 马会勤. 大豆异黄酮代谢途径在大肠杆菌中的构建及表达. 生物工程学报, 2007,23(6):1022-1028. Chen S W, Hao J, Ma H Q. Construction and expression of the soybean isoflavonoid biosynthetic pathway in Escherichia coli. Chinese Journal of Biotechnology, 2007,23(6):1022-1028.
[23] Sevrioukova I F, Li H, Zhang H, et al. Structure of a cytochrome P450-redox partner electron-transfer complex. Proceedings of the National Academy of Sciences of the United States of America, 1999,96(5):1863-1868.
[24] Barnes H J, Arlotto M P, Waterman M R. Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, 1991,88(13):5597-5601.
[25] Katsuyama Y, Miyahisa I, Funa N, et al. One-pot synthesis of genistein from tyrosine by coincubation of genetically engineered Escherichia coli and Saccharomyces cerevisiae cells. Applied Microbiology and Biotechnology, 2007,73(5):1143-1149.
[26] Trantas E, Panopoulos N, Ververidis F. Metabolic engineering of the complete pathway leading to heterologous biosynthesis of various flavonoids and stilbenoids in Saccharomyces cerevisiae. Metabolic Engineering, 2009,11(6):355-366.
[27] Leonard E, Koffas M A. Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli. Applied and Environmental Microbiology, 2007,73(22):7246-7251.
[28] Formica J V, Regelson W. Review of the biology of quercetin and related bioflavonoids. Food and Chemical Toxicology, 1995,33(12):1061-1080.
[29] Lamson D W, Brignall M S. Antioxidants and cancer, part 3: quercetin. Journal of Clinical Therapeutic, 2000,5(3):196-208.
[30] Leonard E, Yan Y, Koffas M A. Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli. Metabolic Engineering, 2006,8(2):172-181.
[31] Kahkonen M P, Heinonen M. Antioxidant activity of anthocyanins and their aglycons. Journal of Agricultural and Food Chemistry, 2003,51(3):628-633.
[32] Noda Y, Kneyuki T, Igarashi K, et al. Antioxidant activity of nasunin, an anthocyanin in eggplant peels. Toxicology, 2000,148(2-3):119-123.
[33] Yan Y, Chemler J, Huang L, et al. Metabolic engineering of anthocyanin biosynthesis in Escherichia coli. Applied and Environmental Microbiology, 2005,71(7):3617-3623.
[34] Yan Y, Li Z, Koffas M A. High-yield anthocyanin biosynthesis in engineered Escherichia coli. Biotechnology and Bioengineering, 2008,100(1):126-140.
[35] Higdon J V, Frei B. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Critical Reviews in Food Science and Nutrition, 2003,43(1):89-143.
[36] Muramatsu K, Fukuyo M, Hara Y. Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats. Journal of Nutritional Science and Vitaminology, 1986,32(6):613-622.
[37] Nagao T, Meguro S, Hase T, et al. A catechin-rich beverage improves obesity and blood glucose control in patients with type 2 diabetes. Obesity, 2009,17(2):310-317.
[38] Chemler J A, Lock L T, Koffas M A, et al. Standardized biosynthesis of flavan-3-ols with effects on pancreatic beta-cell insulin secretion. Applied Microbiology and Biotechnology, 2007,77(4):797-807.
[39] Kim H, Park B S, Lee K G, et al. Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. Journal of Agricultural and Food Chemistry, 2005,53(22):8537-8541.
[40] Bao M, Lou Y. Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK. European Journal of Pharmacology, 2006,547(1-3):22-30.
[41] Castrillo J L, Carrasco L. Action of 3-methylquercetin on poliovirus RNA replication. Journal of Virology, 1987,61(10):3319-3321.
[42] Kim M J, Kim B G, Ahn J H. Biosynthesis of bioactive O-methylated flavonoids in Escherichia coli. Applied Microbiology and Biotechnology, 2013,97(16):7195-7204.
[43] Zhang W Y, Lee J J, Kim I S, et al. 7-O-methylaromadendrin stimulates glucose uptake and improves insulin resistance in vitro. Biological & Pharmaceutical Bulletin, 2010,33(9):1494-1499.
[44] Malla S, Koffas M A, Kazlauskas R J, et al. Production of 7-O-methyl aromadendrin, a medicinally valuable flavonoid, in Escherichia coli. Applied and Environmental Microbiology, 2012,78(3):684-694.
[45] Kramer C M, Prata R T, Willits M G, et al. Cloning and regiospecificity studies of two flavonoid glucosyltransferases from Allium cepa. Phytochemistry, 2003,64(6):1069-1076.
[46] Thuan N H, Park J W, Sohng J K. Toward the production of flavone-7-O-β-d-glucopyranosides using Arabidopsis glycosyltransferase in Escherichia coli. Process Biochemistry,2013,48(11):1744-1748.
[47] Soundararajan R, Wishart A D, Rupasinghe H P, et al. Quercetin 3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing sterol regulatory element-binding protein-2-mediated cholesterol biosynthesis. The Journal of Biological Chemistry, 2008,283(4):2231-2245.
[48] Juergenliemk G, Boje K, Huewel S, et al. In vitro studies indicate that miquelianin (quercetin 3-O-beta-D-glucuronopyranoside) is able to reach the CNS from the small intestine. Planta Medica, 2003,69(11):1013-1017.
[49] Yoon J A, Kim B G, Lee W J, et al. Production of a novel quercetin glycoside through metabolic engineering of Escherichia coli. Applied and Environmental Microbiology, 2012,78(12):4256-4262.
[50] Walsh C T. Combinatorial biosynthesis of antibiotics: challenges and opportunities. Chembiochem, 2002,3(2-3):125-134.
[51] Katsuyama Y, Funa N, Miyahisa I, et al. Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli. Chemistry & Biology, 2007,14(6):613-621.
[52] Chemler J A, Yan Y, Leonard E, et al. Combinatorial mutasynthesis of flavonoid analogues from acrylic acids in microorganisms. Organic Letters, 2007,9(10):1855-1858.
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