工业微生物解脂耶氏酵母及其应用研究<sup>*</sup>

doi:10.13523/j.cb.2004055

中国生物工程杂志

2020, Vol. 40

Issue (9): 77-86 DOI: 10.13523/j.cb.2004055

综述

工业微生物解脂耶氏酵母及其应用研究^*

宋以梅¹,贾秀伟²,李树标²,高翠娟^1,^**(

)

1临沂大学生命科学学院临沂 276000
2阜丰集团有限公司临沂 276000

Industrial Microorganism of Yarrowia lipolytica and Its Industrial Amplicaiton

SONG Yi-mei¹,JIA Xiu-wei²,LI Shu-biao²,GAO Cui-juan^1,^**(

)

1 School of Life Science, Linyi University, Linyi 276000, China
2 Shandong Fufeng Fermentation Co., Ltd, Linyi 276000, China

全文: PDF(3887 KB) HTML

摘要：

解脂耶氏酵母是一种可利用多种底物发酵生产多种产品的非常规酵母,环境适应性强、易培养、安全性高。因此,该物种作为一种新型的生物工程菌株引起了科学界的广泛关注。近年来,工业生物技术因绿色、循环、低碳等优势成为新兴工业技术,在国内外得到了快速发展。介绍了解脂耶氏酵母的特征及其代谢生产各类化合物的方法,并通过对工业生物技术与传统化学化工技术的比较分析,阐述了工业生物技术的特点、研究现状及应用前景。

关键词： 解脂耶氏酵母; 代谢生产; 工业生物技术

Abstract:

Yarrowia lipolytica is an unconventional yeast with the ability to produce a variety of products using diversified substrates. It can survive in diverse environment and is easy to cultivation. It is generally regarded as safe. Y. lipolytica was considered as a new biotechnological strain that has attracted increasing attentions in the scientific research field. In recent years, an emerging industrial technology, industrial biotechnology has developed rapidly worldwide due to its advantages of green, recycling and low carbon. The characteristics of the Y. lipolytica, as well its application in producing high-value compounds were reviewed. Meanwhile, the characteristics and research status of industrial biotechnology were described and the difference between industrial biotechnology and traditional chemical technology was listed. Finally, the application prospect of industrial biotechnology in Y. lipoiytica was discussed.

Key words: Yarrowia lipolytica Metabolic production Industrial biotechnology

收稿日期: 2020-04-29 出版日期: 2020-10-12

ZTFLH:

Q939.97

基金资助: * 国家自然科学基金(31700074);2019年省级大学生创新创业项目(201910452050)

通讯作者: 高翠娟 E-mail: gaocuijuan@lyu.edu.cn

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引用本文:

宋以梅,贾秀伟,李树标,高翠娟. 工业微生物解脂耶氏酵母及其应用研究^*[J]. 中国生物工程杂志, 2020, 40(9): 77-86.

SONG Yi-mei,JIA Xiu-wei,LI Shu-biao,GAO Cui-juan. Industrial Microorganism of Yarrowia lipolytica and Its Industrial Amplicaiton. China Biotechnology, 2020, 40(9): 77-86.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2004055 或 https://manu60.magtech.com.cn/biotech/CN/Y2020/V40/I9/77

表1 工业生物技术与传统化学工业技术的比较分析

图1 解脂耶氏酵母的二型性转换

图2 解脂耶氏酵母的基础代谢途径

图3 解脂耶氏酵母赤藓糖醇的合成途径

图4 细胞质MVA途径与质粒MEP途径

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