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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2020, Vol. 40 Issue (7): 70-81    DOI: 10.13523/j.cb.1912042
综述     
药物输送系统中Janus纳米粒子的制备及应用 *
杨威1,2,宋方祥3,王帅1,2,张黎3,王红霞3,李焱1,2,**()
1 贵州大学药学院 贵阳 550025
2 贵州省药物合成重点实验室 贵阳 550025
3 贵州大学化学与化工学院 贵阳 550025
Preparation and Application of Janus Nanoparticles in Drug Delivery System
YANG Wei1,2,SONG Fang-xiang3,WANG Shuai1,2,ZHANG Li3,WANG Hong-xia3,LI Yan1,2,**()
1 School of Pharmacy,Guizhou University, Guiyang 550025, China
2 Key Laboratory of Pharmaceutical Synthesis,Guizhou University, Guiyang 550025, China
3 School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, China
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摘要：

Janus纳米粒子(Janus nanoparticle,JNP)用于描述由两个不同侧面组合而成的一种异质结构的实体材料。Janus纳米粒子每个侧面在化学性质和/或极性上都有所差异,可将不同材料的特征和功能结合在一起,这是同类均质的材料难以实现的。近年来,Janus纳米粒子的制备方法已取得了重大突破,但其应用的发展方向仍然是一个充满挑战的领域,其中在抗肿瘤药物输送系统领域的研究较为突出。主要介绍了在药物输送系统中Janus纳米粒子的制备方法及应用,并提出了研究前景和可能面临的挑战。
关键词： Janus纳米粒子;  制备;  抗肿瘤;  药物输送    
Abstract:

Janus nanoparticles (JNPs) are used to describe a heterogeneous solid material composed of two different sides. Each side of JNPs is different in chemical nature and/or polarity, and can combine the characteristics and functions of different materials, which is difficult to achieve with homogeneous materials of the same kind. In recent years, major breakthroughs have been made in the preparation of JNPs, but the development direction of its application is still a challenging field, among which the research in the field of antitumor drug delivery systems is more prominent. The preparation method and application of Janus nanoparticles in drug delivery system, and puts forward the research prospects and possible challenges were mainly introduced.
Key words: Janus nanoparticles    Preparation    Anti-tumor    Drug delivery
收稿日期: 2019-12-23 出版日期: 2020-08-13
ZTFLH:  TB34  
基金资助: * 贵州省科学技术基金资助项目(黔科合基础[2020]1Y090)
通讯作者: 李焱     E-mail: yanli@gzu.edu.cn
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引用本文:

杨威,宋方祥,王帅,张黎,王红霞,李焱. 药物输送系统中Janus纳米粒子的制备及应用 *[J]. 中国生物工程杂志, 2020, 40(7): 70-81.

YANG Wei,SONG Fang-xiang,WANG Shuai,ZHANG Li,WANG Hong-xia,LI Yan. Preparation and Application of Janus Nanoparticles in Drug Delivery System. China Biotechnology, 2020, 40(7): 70-81.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.1912042    或    https://manu60.magtech.com.cn/biotech/CN/Y2020/V40/I7/70

图1  不同类型的Janus纳米粒子 [14]
图2  双靶向MSN的作用机制:细胞靶向和线粒体靶向[37]
图3  SPIONs作为靶向给药系统的多功能JNPs的制备[39]
图4  AuNC/Fe(OH)3-PAA JNPs的制备、改性及应用原理[40]
图5  叶酸靶向的Janus纳米粒子,具有ICG和银离子在近红外辐照下的释放行为,用于肝癌协同化疗/光热治疗[43]
图6  枇杷状Janus药物递送系统[47]
图7  Janus AuNSt-MSNP的纳米器件N1和通过2-硝基苄基衍生物5的光解离的NIR光触发药物递送机制[51]
图8  雪人状Janus纳米粒子的制备过程
图9  Au@Ag纳米棒@ZIF-8纳米颗粒(NPs)的合成路线及应用[64]
图10  采用各向异性诱导生长法合成Janus介孔二氧化硅纳米复合材料[65]
Type Composition Morphology Fabrication method Loading capacity Cell viability Ref.
Single structure JNPs FA-MSN-TPP Sphere Modified Sto?bermethod TOP, 5 wt% LNCaP, 45%(100μg/ml) [37]
DOX-PCL-SPION-sPEG-FA Sphere Pickering emulsion technique. - Rat C6 Glioma Cell Line, 50%
(100μg/ml)		 [39]
Composite structure JNPs PCL-AuNC/Fe(OH)3-PAA Cage+Sphere Surface nucleation and seeded growth DOX, 20 wt% Dtxl, 5 wt% HepG-2, 20% (6.25μg/ml) [40]
FA-JNPs@ICG Rod Modified sol-gel method ICG, 4.9 wt% SMMC-7721, 30% (100μg/ml) [43]
JGSMD Loquat Seeded growth DOX, 7.71 wt% - [47]
AuNSt-MSNP Star-Sphere Seeded growth DOX, 9.5 wt% HeLa, 70%(100μg/ml) [51]
FA-PEG-Au/Fe3O4@C Snowman Surface nucleation and seeded growth DOX, 42.9 wt% HeLa, 10%(50μg/ml) [57]
Au@Ag nanorod@ZIF-8 Rod Seeded growth DOX, 37.62 wt% HeLa, 65%(250μg/ml) [64]
UCNP@SiO2@mSiO2&PMO Cube+Sphere Surface nucleation and seeded growth DOX, 5.4 wt% PTX, 6.6 wt% HeLa,50%(50μg/ml) [65]
表1  不同类型药物输送Janus纳米粒子的组成、形貌、制备方法、载药率及对肿瘤细胞活性的分析
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