基因治疗及细胞治疗发展态势分析 <sup>*</sup>

2019, Vol. 39

Issue (5): 43-52 DOI: 10.13523/j.cb.20190505

生物医药国际研发态势专刊

基因治疗及细胞治疗发展态势分析 ^*

迟培娟¹,陈芳¹,Cynthia Liu²,Qiongqiong Zhou²,Yi Deng²,Yingzhu Li²,韩涛¹,余敏²,杨艳萍^1,^**(

),王学昭^1,^**(

)

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收稿日期: 2019-04-15 出版日期: 2019-06-04

基金资助: * 中国科学院文献情报中心特色情报产品研发专项(院1751)资助项目

通讯作者: 杨艳萍,王学昭 E-mail: yangyp@mail.las.ac.cn;wangxz@mail.las.ac.cn

迟培娟,陈芳,Cynthia Liu,Qiongqiong Zhou,Yi Deng,Yingzhu Li,韩涛,余敏,杨艳萍,王学昭. 基因治疗及细胞治疗发展态势分析 ^*[J]. 中国生物工程杂志, 2019, 39(5): 43-52.

图1 全球基因治疗及细胞治疗相关论文和专利数量年度趋势

图2 我国基因治疗及细胞治疗相关论文和专利数量发展趋势

图3 全球基因治疗及细胞治疗文献的主题演化分析

图4 中国基因治疗及细胞治疗文献的主题分析

图5 基因治疗及细胞治疗主要国家分布 (中国,不含港澳台地区,下同)

图6 基因治疗及细胞治疗主要国家/地区技术流向 (箭头的粗细与专利布局的数量呈正相关)

表1 基因治疗及细胞治疗论文全球及中国TOP 10机构

表2 基因治疗及细胞治疗专利全球及中国TOP 10机构

图7 基因治疗及细胞治疗主要药物物质分布趋势

图8 基因治疗及细胞治疗主要药物与疾病的关联

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[5]	KYMRIAH (tisagenlecleucel) product information. [2018-07-03]. https://www.fda.gov/biologicsbloodvaccines/cellulargenetherapyproducts/approvedproducts/ucm573706.htm
[6]	FDA approves CAR-T cell therapy to treat adults with certain types of large B-cell lymphoma. [2018-07-13].. https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm581216.htm
[7]	Gene therapy market expected to reach $4402 million, globally, by 2023. [ 2018-09-13]. https://www.alliedmarketresearch.com/press-release/gene-therapy-market.html.
[8]	Statement from FDA Commissioner Scott Gottlieb, M.D.and Peter Marks, M.D., Ph.D., Director of the Center for Biologics Evaluation and Research on new policies to advance development of safe and effective cell and gene therapies. [2018-10-21]. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm629493.htm

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