<i>Mecp2</i>影响Rett综合征中代谢功能的研究进展 <sup>*</sup>

doi:10.13523/j.cb.2011012

中国生物工程杂志

2021, Vol. 41

Issue (2/3): 89-97 DOI: 10.13523/j.cb.2011012

综述

Mecp2影响Rett综合征中代谢功能的研究进展 ^*

蔡润泽^1,²,王正波^1,²,陈永昌^1,^2,^**(

)

1 昆明理工大学灵长类转化医学研究院昆明 650500
2 省部共建非人灵长类生物医学国家重点实验室昆明 650500

Research Progress of Mecp2 Affecting Metabolic Function in Rett Syndrome

CAI Run-ze^1,²,WANG Zheng-bo^1,²,CHEN Yong-chang^1,^2,^**(

)

1 Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China
2 State Key Laboratory of Primate Biomedical Research, Kunming 650500, China

全文: PDF(474 KB) HTML

摘要：

Rett综合征(RTT)是一种由X连锁的甲基CpG结合蛋白2(Mecp2)基因突变引起的神经系统疾病,突变致病的具体调节机制尚不清楚。对RTT的研究大多聚焦在中枢神经系统,越来越多的研究显示Mecp2在各种代谢系统中也发挥着重要作用。回顾了RTT发展历史、Mecp2的发现及主要作用,并综述了MeCP2在脂质代谢、线粒体代谢和细胞自噬等方面的研究进展。总体而言,Mecp2突变会影响患者体内胆固醇和脂肪代谢,最终导致体型肥胖和肝功能障碍,线粒体形态和功能发生变化,细胞自噬过程发生紊乱,而以上代谢发生紊乱会导致RTT患者的生活质量严重下降。这些发现为进一步理解RTT发生机制、探寻可能的治疗靶点提供了一定的理论依据。

关键词： Rett综合征; Mecp2; 脂质代谢; 线粒体代谢; 细胞自噬

Abstract:

Rett syndrome (RTT) is a neurological disease caused by mutations in the X-linked gene methyl CpG binding protein 2 (Mecp2). RTT occurs mostly in girls, but the mechanism that Mecp2 mutations caused RTT symptoms is largely unknown. The recent studies of RTT mostly focus on the role that Mecp2 plays in the central nervous system. This article reviews the development history of RTT, the discovery and main effects of Mecp2, and then discusses the research progress of MeCP2 in lipid metabolism, mitochondrial metabolism, and autophagy. Overall, Mecp2 mutations can affect cholesterol and fat metabolism in patients and lead to body obesity and liver dysfunction; the morphology and function mitochondrial changes and the disorders of autophagy occur. Because of the above metabolic disorders, the quality of life of RTT patients is seriously reduced. These findings provide a theoretical basis for exploring the mechanism of RTT deeply and screening possible therapeutic targets.

Key words: Rett syndrome Mecp2 Lipid metabolism Mitochondrial metabolism Cell autophagy

收稿日期: 2020-11-05 出版日期: 2021-04-08

ZTFLH:

Q819

基金资助: * 国家自然科学基金资助项目(U1602224)

通讯作者: 陈永昌 E-mail: chenyc@lpbr.cn

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引用本文:

蔡润泽,王正波,陈永昌. Mecp2影响Rett综合征中代谢功能的研究进展 ^*[J]. 中国生物工程杂志, 2021, 41(2/3): 89-97.

CAI Run-ze,WANG Zheng-bo,CHEN Yong-chang. Research Progress of Mecp2 Affecting Metabolic Function in Rett Syndrome. China Biotechnology, 2021, 41(2/3): 89-97.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2011012 或 https://manu60.magtech.com.cn/biotech/CN/Y2021/V41/I2/3/89

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