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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2021, Vol. 41 Issue (2/3): 70-77    DOI: 10.13523/j.cb.2008125
综述     
基于纳米信号标签的表面增强拉曼散射在病原菌检测中的应用 *
周紫卉1,2,刘晓娴1,2,黄昊1,肖瑞2,祁克宗1,**(),王升启2,**()
1 安徽农业大学 合肥 230036
2 军事医学研究院 辐射医学研究所 北京 100850
Application of Surface-enhanced Raman Scattering Based onNano-signal Tags in Pathogen Detection
ZHOU Zi-hui1,2,LIU Xiao-xian1,2,HUANG Hao1,XIAO Rui2,QI Ke-zong1,**(),WANG Sheng-qi2,**()
1 Anhui Agricultural University, Hefei 230036, China
2 Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
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摘要：

表面增强拉曼散射(surface-enhanced Raman scattering, SERS)技术由于其灵敏度高、检测速度快、高特异性和无损等优点,在病原菌检测领域受到了广泛的关注。主要总结了近年来基于纳米信号标签的SERS方法在检测病原菌领域中的研究进展,并介绍了多功能SERS检测平台的构建及在病原菌检测中的应用。最后,对SERS这一技术作为实时、高效和可靠的病原菌检测工具的未来发展进行了展望。
关键词： 表面增强拉曼散射;  拉曼标签;  病原菌;  快速检测    
Abstract:

The surface-enhanced Raman scattering (SERS) technology has received extensive attention in the field of pathogen detection due to its prominent advantages of high sensitivity, rapid detection, high specificity and non-destructive characterization.The research progress of marker-based SERS methods in the field of pathogen detection in recent years was summarized. Moreover, the construction and application of a multifunctional SERS detection platform for pathogenic bacteria were introduced. Finally, the future development of SERS as a real-time, efficient and reliable tool for detecting pathogens is prospected.
Key words: Surface-enhanced Raman scatter    Lable-based SERS    Pathogenic bacteria    Rapid detection
收稿日期: 2020-08-17 出版日期: 2021-04-08
ZTFLH:  Q819  
基金资助: * 安徽高校协同创新项目资助项目(GXXT-2019-035)
通讯作者: 祁克宗,王升启     E-mail: qkz@ahau.edu.cn
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周紫卉
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引用本文:

周紫卉,刘晓娴,黄昊,肖瑞,祁克宗,王升启. 基于纳米信号标签的表面增强拉曼散射在病原菌检测中的应用 *[J]. 中国生物工程杂志, 2021, 41(2/3): 70-77.

ZHOU Zi-hui,LIU Xiao-xian,HUANG Hao,XIAO Rui,QI Ke-zong,WANG Sheng-qi. Application of Surface-enhanced Raman Scattering Based onNano-signal Tags in Pathogen Detection. China Biotechnology, 2021, 41(2/3): 70-77.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2008125    或    https://manu60.magtech.com.cn/biotech/CN/Y2021/V41/I2/3/70

图1  用于细菌检测的基于标签和基于无标签的SERS方法的示意图
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