新的药物传递系统:外泌体作为药物载体递送<sup>*</sup>

doi:10.13523/j.cb.2005026

中国生物工程杂志

2020, Vol. 40

Issue (9): 28-35 DOI: 10.13523/j.cb.2005026

综述

新的药物传递系统:外泌体作为药物载体递送^*

吴忧,辛林(

)

南昌大学第二附属医院南昌 330006

New Drug Delivery System: Delivery of Exosomes as Drug Carriers

WU You,XIN Lin(

)

Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China

全文: PDF(1008 KB) HTML

摘要：

外泌体(exosomes)是细胞分泌的囊泡,在细胞与细胞之间通信中发挥重要作用。由于其固有的长距离通信能力和出色的生物相容性而具有很大的潜力作为药物递送载体,尤其适合递送蛋白质、核酸、基因治疗剂等治疗药物。许多研究表明外泌体可以有效地将许多不同种类的货物递送至靶细胞,因此,它们常被作为药物载体用于治疗。对外泌体作为药物递送系统中面临的外泌体分离,药物装载和靶向治疗应用的进展与挑战作一介绍,以期更好为外泌体药物递送系统开发提供新思路。

关键词： 外泌体; 药物载体; 靶向治疗

Abstract:

Exosomes are the substance that are released by most types of cells and have an important role in cell to cell communication. They also have great potential as a medicine delivery carrier, especially suitable for delivery of therapeutic drugs, such as proteins, nucleic acids and gene therapeutic agents due to the inherent long-distance communication capacity and excellent biocompatibility. Many studies show that exosome can efficiently deliver many different kinds of cargo to the target cell. Therefore, they are often used to deliver therapeutic cargo for treatment. As a result, the literature will introduce the advances and challenge facing exosomes as drug delivery systems, such as exosome isolation, drug loading and targeting therapy application, with the expectation of better delivering new ideas for the development of exosomal drug delivery systems.

Key words: Exosomes Drug delivery Targeted therapy

收稿日期: 2020-05-14 出版日期: 2020-10-12

ZTFLH:

Q819

基金资助: * 国家自然科学基金(81872480);国家自然科学基金(81760549);国家自然科学基金(81560492)

通讯作者: 辛林 E-mail: xlyxbs@126.com

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引用本文:

吴忧,辛林. 新的药物传递系统:外泌体作为药物载体递送^*[J]. 中国生物工程杂志, 2020, 40(9): 28-35.

WU You,XIN Lin. New Drug Delivery System: Delivery of Exosomes as Drug Carriers. China Biotechnology, 2020, 40(9): 28-35.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2005026 或 https://manu60.magtech.com.cn/biotech/CN/Y2020/V40/I9/28

表1 外泌体提取技术、方法和优缺点

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