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中国生物工程杂志

CHINA BIOTECHNOLOGY
中国生物工程杂志
中国生物工程杂志  2020, Vol. 40 Issue (9): 43-51    DOI: 10.13523/j.cb.2005024
综述     
铜绿假单胞菌中鼠李糖脂生物合成的研究进展*
段海荣1,3,魏赛金1,3,黎循航2,3,**()
1江西农业大学生物科学与工程学院 南昌 330045
2豫章师范学院 南昌 330103
3江西农业大学 应用微生物研究所 南昌 330045
Advances in Rhamnolipid Biosynthesis by Pseudomonas aeruginosa Research
DUAN Hai-rong1,3,WEI Sai-jin1,3,LI Xun-hang2,3,**()
1 College of Biological Science and Engineering, Jiangxi Agricultural University, Nanchang 330045,China
2 Yuzhang Normal University, Nanchang 330103,China
3 Institute of Applied Microbiology Jiangxi Agricultural University, Nanchang 330045,China
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摘要：

鼠李糖脂因其具有环境友好和卓越的物理化学特性,而有望成为化学合成表面活性剂的替代物。近年来鼠李糖脂得到了广泛的研究,其目的是利用低价的可再生资源进行大规模生产,但目前的研究成果仍不足以选育出更具商业竞争力的鼠李糖脂过量合成菌株。为此,进一步理解鼠李糖脂生物合成的复杂基因调控网络,探索降低生产成本的发酵工艺势在必行。综述了铜绿假单胞菌中鼠李糖脂的生物合成途径、群体感应对主要基因的调控、鼠李糖脂在生物膜形成中所发挥的作用,以及发酵优化对鼠李糖脂产量的影响。有助于加深对鼠李糖脂生物合成的认识,为提高鼠李糖脂产量提供重要参考信息。
关键词： 鼠李糖脂;  生物合成;  群体感应;  生物膜;  铜绿假单胞菌    
Abstract:

Rhamnolipids have emerged as a very promising alternatives to their chemo-synthetic counterparts, due to their environmental compatibility and the remarkable physicochemical properties. In recent years, rhamnolipids have been intensively studied, aiming to large-scale improve the production of rhamnolipids based on low-cost renewable resources. However, the current findings are insufficient to screen over-producing rhamnolipids strains with competitive commercial values. Therefore, it is imperative to in-depth understand the sophisticated gene regulatory network of rhamnolipids biosynthesis and explore the fermentation technology to lower the costs. The biosynthetic pathways and the main gene regulatory factors by quorum sensing involved in rhamnolipids production within Pseudomonas aeruginosa are presented, followed by the role of in biofilm formation, and the effect of fermentation optimization on rhamnolipids yield. It is helpful to enhance our understanding on rhamnolipids biosynthesis and provide important reference information for improving the yield of rhamnolipids.
Key words: Rhamnolipid    Biosynthesis    Quorum sensing    Biofilm    Pseudomonas aeruginosa
收稿日期: 2020-05-13 出版日期: 2020-10-12
ZTFLH:  Q819  
基金资助: * 国家自然科学基金(31460469)
通讯作者: 黎循航     E-mail: li_xunh@126.com
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段海荣
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段海荣,魏赛金,黎循航. 铜绿假单胞菌中鼠李糖脂生物合成的研究进展*[J]. 中国生物工程杂志, 2020, 40(9): 43-51.

DUAN Hai-rong,WEI Sai-jin,LI Xun-hang. Advances in Rhamnolipid Biosynthesis by Pseudomonas aeruginosa Research. China Biotechnology, 2020, 40(9): 43-51.

链接本文:

https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.2005024    或    https://manu60.magtech.com.cn/biotech/CN/Y2020/V40/I9/43

图1  铜绿假单胞菌鼠李糖脂生物合成途径
图2  铜绿假单胞菌的群体感应系统
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