斑马鱼hoxa1a基因调控颅面骨骼发育的功能研究*

武秀知,王宏杰,祖尧

Functional Study of hoxa1a Regulating Craniofacial Bone Development in Zebrafish

Xiu-zhi WU,Hong-jie WANG,Yao ZU

图5 hoxa1a缺失导致斑马鱼幼鱼面部软骨发育缺陷、筛骨板断裂

Fig.5 The loss of hoxa1a resulted in defective facial cartilage development and ethmoid plate rupture in juvenile zebrafish (a),(b) The results of cartilage staining of wildtype juvenile zebrafish at 1 month showed normal ethmoid plate and normal development of pharyngeal arch (c),(d) The cartilage staining results of hoxa1a-/- at 1 month showed that the ethmoid plate was broken, as shown by the black arrow. The gill arch was lightly stained and was abnormal development, as shown by the red arrow. There was also a loss of cartilage at the anterior end of the first pharyngeal arch, as shown by the green arrow. Scale bar: 0.5 mm