斑马鱼hoxa1a基因调控颅面骨骼发育的功能研究*

武秀知,王宏杰,祖尧

Functional Study of hoxa1a Regulating Craniofacial Bone Development in Zebrafish

Xiu-zhi WU,Hong-jie WANG,Yao ZU

图4 斑马鱼成鱼硬骨染色表明hoxa1a纯合突变体面部颅骨发育缺陷、筛骨板断裂

Fig.4 Alizarin red staining of adult hoxa1a-/- zebrafish showed defective skull development and rupture of ethmoid plate (a),(b) Alizarin red staining of wildtype at 3 months showed normal ethmoid plate (c),(d) Alizarin red staining of homozygous hoxa1a mutant at 3 months showed rupture of ethmoid plate, as shown by the red arrow (e),(f) Alizarin red staining of wildtype 1 year old wildtype zebrafish showed normal ethmoid plates (g),(h) Alizarin Red Staining of homozygous hoxa1a mutant zebrafish of 1 year old indicated a rupture of the ethmoid plate, as shown by the red arrow. And the hoxa1a-/- had abnormal mouth shape, as shown by the green arrow. a, c, e, g scale bar: 0.5 mm; b, d, f, h scale bar: 1 mm