群体感应系统在合成生物学中的应用*

郑义,郭世英,隋凤翔,杨骐羽,卫雅萱,李晓岩

Applications of Quorum Sensing Systems in Synthetic Biology

Yi ZHENG,Shi-ying GUO,Feng-xiang SUI,Qi-yu YANG,Ya-xuan WEI,Xiao-yan LI

图2 利用群体感应系统调控工程菌在生物基化学品生产、生物电化学转化以及医学领域的应用

Fig.2 Application of quorum sensing system to control engineering bacteria in biochemical production, bioelectrochemical transformation and medical fields Design engineering bacteria through the mutual combination of orthogonality quorum sensing system, quorum sensing system and a variety of technology combined with the exquisite design sense of self-induced substances, light, heat, metal ions, nucleic acid, antibodies and other signals, express the corresponding characters. (1) In the field of biochemistry production: dynamically regulate population density, inhibit the pathway of substrate conversion to non-target metabolites, so as to maximize substrate utilization; (2) In the field of bioelectrochemistry: induction and enhancement of group sensing system through electrical signals; (3) In the field of biomedicine: through the activation of visual signals for the detection of diseases, the construction of a new drug delivery system based on the characteristics of engineering bacteria