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中国生物工程杂志

China Biotechnology
China Biotechnology
China Biotechnology  2021, Vol. 41 Issue (12): 116-124    DOI: 10.13523/j.cb.2107047
    
A Study of Interdisciplinarity in Biosafety Research Based on Discipline Categories and Enrichment Analysis
MA Li-li1,YI Pan-pan1,AO Ni-hua2,JIAO Hong-tao3,LEI Rui-peng4,LIU Huan5,6,**()
1 Wuhan Library of Chinese Academy of Sciences, Hubei Key Laboratory of Big Data in Science and Technology, Wuhan 430071, China
2 National Science Library, Chinese Academy of Sciences, Beijing 100190, China
3 Institute of Data Law, Jiangxi University of Finance and Economics, Nanchang 330032, China
4 School of Philosophy, Huazhong University of Science and Technology, Wuhan 430074, China
5 School of Humanities and Social Sciences, University of Science and Technology of China, Hefei 230026, China
6 Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
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Abstract  

With the development of synthetic biology, gene editing and other typical dual-use emerging biotechnology, biosafety, as a significant interdisciplinary area, has attracted wide attention. Using the papers data from Web of Science, this study analyzed the interdisciplinary status and temporal evolution of biosafety research based on journal discipline category, and studied the differences of interdisciplinary tendency in different countries by enrichment analysis. The results show that since the 20th century, the interdisciplinarity of biosafety research and other disciplines has become more extensive. Animal and plant science, environment and ecology, social science, microbiology and agricultural science are the most interdisciplinary areas. The interdisciplinary situation of biosafety research in different countries was different, and the interdisciplinary situation in American and European countries has a valuable reference for China. This study is expected to provide a exploration of new methods for interdisciplinary study research in specific research fields, and to provide reference for strengthening the interdisciplinary and exploring new research directions of biosafety research in our country.

Key words： Biosafety      Interdisciplinarity      Discipline category      Bibliometrics      Enrichment analysis     
Received: 21 July 2021      Published: 13 January 2022
ZTFLH:  Q81G35  
Corresponding Authors: Huan LIU     E-mail: liuhuan520@ustc.edu.cn
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Li-li MA
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Huan LIU
Cite this article:

MA Li-li,YI Pan-pan,AO Ni-hua,JIAO Hong-tao,LEI Rui-peng,LIU Huan. A Study of Interdisciplinarity in Biosafety Research Based on Discipline Categories and Enrichment Analysis. China Biotechnology, 2021, 41(12): 116-124.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2107047     OR     https://manu60.magtech.com.cn/biotech/Y2021/V41/I12/116

Fig.1 The number of papers published and interdisciplinarity in the research field of biosafety during 1981-2020
Fig.2 The interdisciplinary scale between biosafety and other research fields
排名 学科领域 高频关键词(前10个)
1 动植物科学 Risk factors(风险因素)、Epidemiology(流行病学)、Pig(猪)、Avian influenza(禽流感)、Vaccination(接种疫苗)、Poultry(家禽)、Cattle(牛)、Swine(猪)、Surveillance(监控)、Risk assessment(风险评估)
2 环境和生态学 Invasive species(入侵物种)、Biological invasions(生物入侵)、Invasive alien species(外来入侵物种)、Risk assessment(风险评估)、Eradication(根除)、Invasion(入侵)、Alien species(外来物种)、Climate change(环境变化)、Dispersal(传播)、Biodiversity(生物多样性)
3 社会科学 Synthetic biology(合成生物学)、Biotechnology(生物技术)、Bioterrorism(生物恐怖)、Biopolitics(生物政治)、Risk(风险)、Surveillance(监控)、Regulation(法规)、Ethics(伦理)、Dual use(两用性)、Epidemiology(流行病学)
4 微生物学 Diagnosis(诊断)、Nipah virus(尼帕病毒)、SARS-Cov-2、Coronavirus(冠状病毒)、Ebola virus(埃博拉病毒)、酶联免疫吸附测定(ELISA) 、Inactivation(灭活)、生物安全防护水平4级(BSL-4)、Henipavirus(亨尼帕病毒)、Mycobacterium tuberculosis(结核分枝杆菌)
5 农业科学 Risk assessment(风险评估)、Food safety(食品安全)、Quarantine(隔离)、Salmonella(沙门氏菌)、Bacillus thuringiensis(苏云金杆菌)、Biotechnology(生物技术)、Gene flow(基因流)、Genetically modified organisms(转基因生物)、Invasive alien species(外来入侵物种)、Genetic engineering(基因工程)
Table 1 The high frequency keywords in the top five interdisciplinary disciplines of biosafety
Fig.3 Changes of interdisciplinary time series in the research field of biosafety during 1981 -2020
Fig.4 Changes of interdisciplinarity in the research field of biosafety during different time stages (based on WOS subject category system) (a) During 1981-1990 (b) During 1991-2000 (c) During 2001-2010 (d) During 2011-2020
学科 美国 中国 澳大利亚 英国 德国 新西兰 意大利 法国 加拿大 巴西
动植物科学 1.02
(0.26)		 0.27
(5.12×10-104)		 1.36
(1.02×10-14)		 1.11
(0.02)		 0.78
(6.84×10-4)		 1.56
(1.87×10-12)		 1.01
(0.45)		 0.95
(0.29)		 1.35
(2.32×10-5)		 1.08
(0.23)
环境和生态学 0.75
(1.66×10-4)		 0.62
(3.21×10-6)		 2.16
(1.20×10-21)		 1.52
(2.50×10-5)		 0.96
(0.46)		 3.72
(3.30×10-32)		 1.39
(0.03)		 1.38
(0.03)		 1.23
(0.14)		 0.84
(0.28)
社会科学 1.09
(0.13)		 0.09
(1.47×10-32)		 1.16
(0.1)		 2.39
(1.53×10-22)		 0.75
(0.09)		 0.34
(1.03×10-4)		 0.35
(1.90×10-4)		 0.67
(0.06)		 0.88
(0.32)		 1.11
(0.36)
微生物学 1.41
(9.96×10-8)		 0.57
(1.33×10-6)		 0.68
(2.87×10-3)		 0.93
(0.34)		 1.83
(1.70×10-5)		 0.17
(6.41×10-7)		 1.22
(0.16)		 1.43
(0.03)		 1.01
(0.52)		 0.70
(0.13)
生物和生物化学 0.95
(0.27)		 1.38
(7.98×10-5)		 0.41
(3.06×10-8)		 0.84
(0.12)		 1.51
(5.50×10-3)		 0.36
(2.85×10-4)		 0.84
(0.25)		 0.90
(0.37)		 0.83
(0.25)		 0.65
(0.09)
农业科学 0.72
(1.09×10-4)		 0.61
(1.15×10-5)		 1.19
(0.07)		 0.77
(0.04)		 0.49
(2.04×10-3)		 1.04
(0.45)		 0.94
(0.44)		 1.10
(0.35)		 1.04
(0.46)		 2.17
(1.75×10-5)
材料科学 0.56
(1.15×10-9)		 4.53
(2.18×10-199)		 0.29
(2.05×10-11)		 0.13
(1.55×10-15)		 0.32
(3.12×10-5)		 0.44
(2.72×10-3)		 0.20
(8.30×10-6)		 0.49
(9.38×10-3)		 0.07
(4.21×10-6)
临床医学 1.10
(0.14)		 1.33
(1.65×10-3)		 0.44
(2.93×10-6)		 0.52
(2.35×10-4)		 1.30
(0.09)		 0.11
(1.25×10-6)		 1.43
(0.04)		 1.11
(0.35)		 0.70
(0.13)		 2.34
(1.54×10-5)
多学科综合 1.43
(9.80×10-7)		 0.78
(0.02)		 1.28
(0.02)		 1.08
(0.32)		 1.32
(0.08)		 1.07
(0.42)		 0.52
(0.02)		 1.31
(0.12)		 1.23
(0.21)		 0.82
(0.32)
化学 0.56
(9.43×10-7)		 3.04
(4.64×10-48)		 0.11
(2.40×10-13)		 0.19
(3.37×10-9)		 0.53
(0.02)		 0.14
(4.23×10-5)		 1.23
(0.22)		 0.29
(1.81×10-3)		 0.16
(2.36×10-4)		 0.30
(9.54×10-3)
免疫学 1.42
(2.86×10-5)		 0.69
(7.43×10-3)		 0.40
(1.96×10-5)		 1.32
(0.04)		 1.72
(3.91×10-3)		 0.30
(2.48×10-3)		 1.34
(0.13)		 1.77
(6.62×10-3)		 0.87
(0.4)		 1.11
(0.42)
药理学和毒理学 0.90
(0.2)		 2.39
(2.71×10-19)		 0.10
(9.34×10-11)		 0.44
(6.72×10-4)		 0.97
(0.53)		 0.09
(1.12×10-4)		 1.39
(0.12)		 0.57
(0.09)		 0.31
(0.01)		 0.91
(0.49)
分子生物学和
遗传学		 1.12
(0.16)		 1.19
(0.11)		 0.55
(5.05×10-3)		 0.86
(0.28)		 1.87
(2.66×10-3)		 0.29
(6.62×10-3)		 1.61
(0.04)		 2.36
(1.07×10-4)		 0.89
(0.45)		 1.27
(0.28)
物理学 0.63
(0.02)		 4.19
(7.85×10-31)		 0.28
(3.84×10-3)		 0.22
(3.72×10-3)		 0.62
(0.27)		 0.25
(0.09)		 0.26
(0.1)		 0.36
(0.22)
经济和商业 1.60
(3.16×10-3)		 0.40
(9.30×10-3)		 1.94
(4.76×10-3)		 1.47
(0.12)		 0.25
(0.09)		 1.20
(0.43)		 0.31
(0.16)		 0.32
(0.17)		 1.73
(0.16)		 0.44
(0.33)
工程学 0.84
(0.3)		 2.15
(2.63×10-4)		 0.87
(0.46)		 0.51
(0.15)		 0.96
(0.62)		 0.38
(0.26)		 1.19
(0.47)		 0.88
(0.6)		 1.67
(0.27)
神经科学与行为学 0.45
(0.14)		 0.99
(0.64)		 1.41
(0.36)		 1.10
(0.56)		 1.04
(0.63)		 2.57
(0.18)		 2.62
(0.18)		 2.84
(0.15)		 1.80
(0.43)
计算机科学 0.70
(0.43)		 0.51
(0.39)		 3.64
(7.29×10-3)		 1.60
(0.47)		 1.91
(0.41)		 1.98
(0.4)
地球科学 2.25
(0.08)		 0.80
(0.64)		 0.94
(0.71)		 3.06
(0.28)
数学 1.93
(0.45)		 4.00
(0.23)
空间科学 1.93
(0.45)
精神病和心理学
Table 2 The interdisciplinary differences in the research field of biosafety between different countries
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