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中国生物工程杂志

China Biotechnology
China Biotechnology  2013, Vol. 33 Issue (6): 93-98    DOI:
    
Recent Development of Antitumor Peptides
HAN Xiao, LI Na, DU Pei-ge
College of Pharmaceutical Science, Beihua University, Jilin 132013, China
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Abstract  

In recent years, increasing attention has been paid to synthetic antitumor peptides. Despite many technical hurdles, such as the half-life period of most peptides is short, peptides are advantageous because they are small, specific to tumor cells, possess low immunogenicity and are relatively easy to modify and design. Several antitumor peptides and their modified derivatives have advanced to clinical trials. Modern chemotherapy based on synthetic oligopeptides has the potential to provide an effective anti-tumor treatment for cancer patients while minimizing severe side-effects. Here, a review of the potential of novel natural anticancer peptides such as necrotic peptides, apoptotic peptides and function-blocking peptides in the context of their ability to induce tumor regression is presented. And the focus is on the therapeutic prospects of antitumor peptides and their possible application in tumor therapy.



Key wordsAntitumor peptides      Necrotic peptides      Apoptotic peptides      Function-blocking peptides     
Received: 01 November 2012      Published: 25 June 2013
ZTFLH:  R73  
Cite this article:

HAN Xiao, LI Na, DU Pei-ge. Recent Development of Antitumor Peptides. China Biotechnology, 2013, 33(6): 93-98.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2013/V33/I6/93

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