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中国生物工程杂志

China Biotechnology
China Biotechnology  2011, Vol. 31 Issue (03): 101-106    DOI:
    
The Application Prospects of Ovine Adenovirus287 Vector
GU Yuan-xing, WANG Meng, LIU Wen-qian, ZHANG Jie, LIU Yong-sheng
Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046,China
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Abstract  

Ovine adenovirus 287 has a unique genome organization with a length of 29 576bp. The genome is characterized distinctively by a high A/T content (66.4%), the lack of a typical El region, and a long redundant sequence. Three nonessential regions of the viral genome, where 6.3kb foreign genes can be inserted theoretically, have been identified. OAdV287 also has unique fiber and penton, where lacks the integrin-binding domain in penton or any other capsid protein. OAdV287 can infect a wide range of human and animal cell lines, but failing to replicate in non-ovine cell lines. In addition, OAdV287 vector can circumvent the pre-existing human adenoviruses immunity, and so have an efficient transfection. Currently, OAdV287 has become one of the research focuses among the animal adenoviruses vectors.



Key wordsOvine adenovirus      Genome structure      Gene vector      Applications     
Received: 19 October 2010      Published: 01 April 2011
ZTFLH:  Q782  
Corresponding Authors: Gu YuanXing     E-mail: jinguyuan2010@yahoo.cn;liuyongshengvip@sina.com.cn
Cite this article:

GU Yuan-xing, WANG Meng, LIU Wen-qian, ZHANG Jie, LIU Yong-sheng. The Application Prospects of Ovine Adenovirus287 Vector. China Biotechnology, 2011, 31(03): 101-106.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2011/V31/I03/101

[1] Peet R I, Coackley W, Purcell D A, et al. Adenovirus inclusions in sheep liver. Aust Vet J,1983,60(10):307-308.
[2] Benko M, Harrach B. A proposal for a new (third) genus within the family Adenoviridae. Arch Virol,1998,143(4):829-837.
[3] Fauquet C M, Mayo M A, Maniloff J, et al. Virus taxonomy, 8th report of the international committee on taxonomy of viruses. California: Virology division international union of microbiological societies. Elsevier Academic Press, 2005.
[4] Khatri A, Both G W. Identification of transcripts and promoter regions of ovine adenovirus OAV287. Virology, 1998,245(1):128-141.
[5] Davison A, Benko M, Harrach B. Genetic content and evolution of adenoviruses. Journal of General Virology, 2003,84:2895-2908.
[6] Gorman J J, Wallis T P, Whelan D A, et al. LH3, a "homologue" of the mastadenoviral E1B 55-kDa protein is a structural protein of atadenoviruses. Virology, 2005,342(1):159-166.
[7] Vrati S, Boyle D, Kocherhans R, et al. Sequence of ovine adenovirus homologs for 100K hexon assembly, 33K, pVIII, and fiber genes: early region E3 is not in the expected location. Virology, 1995,209(2): 400-408.
[8] Vrati S, Brookes D E, Strike P, et al. Unique genome arrangement of an ovine adenovirus: identification of new proteins and proteinase cleavage sites. Virology, 1996, 220(1):186-199.
[9] Kümin D, Hofmann C, Uckert W, et al. Identification of an ovine atadenovirus gene whose product activates the viral E2 promoter: possible involvement of E2F-1. Virology, 2004,318(1):79-89.
[10] Both G W. Identification of a unique family of F-box proteins in atadenoviruses. Virology, 2002, 304(2): 425-433.
[11] Xu Z Z, Hyatt A, Boyle D B, et al. Construction of ovine adenovirus recombinants by gene insertion or deletion of related terminal region sequences. Virology, 1997,230(1): 62-71.
[12] Gerald W B. Ovine atadenovirus: a review of its biology, biosafety pro?le and application as a gene delivery vector. Immunology and Cell Biology, 2004,82(2):189-195.
[13] Venktesh A, Fujiko W, Both G W, et al. Ovine adenovirus (OAV287) lacks a virus-associated RNA gene. Journal of General Virology, 1998,79:509-516 .
[14] Anurag S, Xiaoxin L, Dinesh S B, et al. Adenovirus receptors and their implications in gene delivery. Virus Research, 2009,143(2):184-194.
[15] Edelstein M L, Abedi M R, Wixon J, et al. Gene therapy clinical trials worldwide 1989-2004-an overview. J Gene Med, 2004,6(6):597-602.
[16] Thacker E E, Timares L, Matthews Q L. Strategies to overcome host immunity to adenovirus vectors in vaccine development. Expert Rev Vaccines, 2009,8(6):761-777.
[17] Dinesh S B, Suresh K M. Development of nonhuman adenoviruses as vaccine vectors. Vaccine, 2006,24(7): 849-862.
[18] Nwanegbo E, Vardas E, Gao W, et al. Prevalence of neutralizing antibodies to adenoviral serotypes 5 and 35 in the adult populations of the Gambia, South Africa, and the United States. Clin Diagn Lab Immunol, 2004,11(2):351-357.
[19] Barouch D H, Nabel G J. Adenovirus vector-based vaccines for human immunode?ciency virus type 1. Hum Gene Ther, 2005,16(2):149-156.
[20] Zaiss A K, Machado H B, Herschman H R. The influence of innate and pre-existing immunity on adenovirus therapy. J Cell Biochem, 2009,108(4):778-790.
[21] Sharma A, Dinesh S B, Tandon M, et al. Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a mouse model. Virology, 2009, 386(1): 44-54.
[22] Hofmann C, Loser P, Cichon G, et al. Ovine adenovirus vectors overcome preexisting humoral immunity against human adenoviruses in vivo. J Virol, 1999,73(8):6930-6936.
[23] Peter L, Günter C, Gary S J, et al. Ovine adenovirus vectors promote efficient gene delivery in vivo. Gene Ther Mol Biol, 1999,4:33-43.
[24] Russell W C. Adenoviruses: update on structure and function. J Gen Virol, 2009, 90:1-20.
[25] Joanna L H , Youn B L, James B, et al. Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells). Cell Biol Toxicol, 2010, 26(1):1-20.
[26] Kalyuzhniy O, Di Paolo N C, Silvestry M, et al. Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo. Proc Natl Acad Sci USA, 2008,105(14):5483-5488.
[27] Xu Z Z, Both G W. Altered tropism of an ovine adenovirus carrying the fiber protein cell binding domain of human adenovirus type 5. Virology, 1998,248(1):156-163.
[28] Loser P, Hillgenberg M, Arnold W, et al. Ovine adenovirus vectors mediate efficient gene transfer to skeletal muscle. Gene Ther, 2000,7(17):1491-1498.
[29] Kumin D, Hofmann C, Rudolph M, et al. Biology of ovine adenovirus infection of nonpermissive cells. J Virol, 2002,76(21):10882-10893.
[30] Lockett L J, Both G W. Complementation of a defective human adenovirus by an otherwise incompatible ovine adenovirus recombinant carrying a functional E1A gene. Virology, 2002, 294(2):333-341.
[31] Voeks D, Martiniello-Wilks R, Madden V, et al. Gene therapy for prostate cancer delivered by ovine adenovirus and mediated by purine nucleoside phosphorylase and ?udarabine in mouse models. Gene Ther, 2002,9(12):759-768.
[32] Martiniello-Wilks R, Dane A, Voeks D J, et al. Gene-directed enzyme prodrug therapy for prostate cancer in a mouse model that imitates the development of human disease. J Gene Med, 2004,6(1):43-54.
[33] Wuest T, Both G W, Prince A M, et al. Recombinant ovine atadenovirus induces a strong and sustained T cell response against the hepatitis C virus NS3 antigen in mice. Vaccine, 2004,22(21-22):2717-2721.
[34] Bridgeman A, Roshorm Y, Lockett L J, et al. Ovine atadenovirus, a novel and highly immunogenic vector in prime-boost studies of a candidate HIV-1 vaccine. Vaccine, 2010, 28(2):474-483.

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