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| The progress of Chloramphenicol and tetracycline inhibit bacterial protein secretion |
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Abstract Both chloramphenicol and tetracycline can inhibit bacterial protein secretion. A protein that is destined for secretion possesses a signal sequence at its amino terminus,which directs it to a translocator complex that is formed by secretion protein complex SecY, E, G, and A proteins. Protein translocation also depends on the folding characteristics of the fusion protein, misfolding of the protein after its translocation into the periplasm can lead to the formation of toxic aggregates. Fast-folding fusion protein can jam the translocator complex, which also leads to cell death (because all protein secretion is inhibited). Antibiotics chloramphenicol and tetracycline treatment bacteria caused the translocation complex in the degradation of SecY, then caused deadly protein jam. In this paper, we overview a new model of the interference mechanism of antibiotics chloramphenicol and tetracycline in bacteria protein synthesis and lead to the degradation of SecY to play inhibit bacterial protein secretion activity, in order to provide a scientific basis for studying new treatments that target the bacteria
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Received: 01 December 2009
Published: 25 August 2010
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