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中国生物工程杂志

China Biotechnology
China Biotechnology  2010, Vol. 30 Issue (03): 119-124    DOI:
    
Manufacturing Process of Daptomycin and Combinatorial Biosynthesis of Derivatives
New Drug Research and Development Center, North China Pharmaceutical Group Corporation and National Microbial Medicine Engineering and Research Center, Shijiazhuang 050015,China
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Abstract  

Since the first approved lipopeptide antibiotics-datomycin launched in 2003, there were increasing indications and bright market prospects of daptomycin, resulting its manufacturing process and structure modification has become the focus of anti-infection drugs research and development.The course of leading compound A21978C and reviewed the evolution of synthetic techniques was traced. Moreover, manufacturing technology, biosynthetic gene clusters of daptomycin, and application of combinatorial biosynthesis in structure of daptomycin were also introduced emphatically.



Key wordsDaptomycin      Cycle lipopeptide antibiotics      Manufacturing process      Fermentation technology      Combinatorial biosynthesis     
Received: 20 May 2009      Published: 25 March 2010
Cite this article:

LIU Ba-Ning, CANG Ji-Yong, ZHANG Hua. Manufacturing Process of Daptomycin and Combinatorial Biosynthesis of Derivatives. China Biotechnology, 2010, 30(03): 119-124.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2010/V30/I03/119

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