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| The Role of Biomacromolecule Phase Separation in Diseases |
ZHOU Xue-yuan,DU He-kang,LU Zeng-zeng,ZHENG Jian-pei,CHEN Qi**( ) |
| Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, Fujian Normal University Qishan Campus, College Town, Fuzhou 350117, China |
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Abstract In order to maintain normal physiological activities, cells have evolved a membrane system, which enables various activities to occur efficiently and in an orderly manner in a specific space and time. The involvement of membrane system in material transport, signal transmission, energy metabolism and other processes has been widely understood, but the molecular details related to the assembly and function of membrane-free compartments have not been thoroughly studied. Biological macromolecules form a variety of membrane-free compartments in cells through phase separation, such as nucleolus, centrosome, and stress particles, which are collectively referred to as biomolecular condensates. As a mechanism of aggregation and separation of cellular biochemical reactions, phase separation is ubiquitous in nature and widely involved in many important physiological processes such as signal transduction and gene transcription regulation. The abnormal phase separation is closely related to many human diseases, such as neurodegenerative diseases, cancer and infectious diseases. By introducing the cellular structure and function of phase separation and its mechanism, this paper will further elaborate the role of phase separation in the occurrence and development of diseases.
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Received: 27 September 2022
Published: 31 March 2023
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Corresponding Authors:
**Qi CHEN
E-mail: nfsw@fjnu.edu.cn
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