Research Progress on the <i>Salmonella typhimurium</i> Invading Host Cells

doi:10.13523/j.cb.2202016

China Biotechnology

2022, Vol. 42

Issue (7): 69-78 DOI: 10.13523/j.cb.2202016

Research Progress on the Salmonella typhimurium Invading Host Cells

Chun-xiao YAN¹,Hao WU^1,²,Hai-hua RUAN³,Lin YUAN¹,Qian-qian SONG¹,Jian-jun QIAO^1,^2,^**(

)

1. Key Laboratory of Systems Bioengineering of Ministry of Education, School of Chemical Engineering, Tianjin University, Tianjin 300072, China
2. Zhejiang Shaoxing Research Institute, Tianjin University, Shaoxing 312000, China
3. Tianjin Key Laboratory of Food Science and Biotechnology, Tianjin 300134, China

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Abstract

Salmonella typhimurium is a zoonotic intestinal pathogen, which can cause intestinal inflammation. Effectors are mainly secreted through the type III secretion system(T3SS) encoded by its pathogenic islands (SPIs) to invade host cells and regulate cell signaling pathways, including pro-inflammatory effectors and anti-inflammatory factors. Pro-inflammatory effectors are released to cause inflammation when Salmonella typhimurium invades intestinal epithelial cells. In order to prevent excessive damage of host cells by pro-inflammatory effectors affecting the survival and reproduction of bacteria, Salmonella typhimurium can produce a series of anti-inflammatory factors to regulate intracellular signaling pathways, co-produce with the host and eventually spread throughout the body to cause severe infection. This paper provides an overview of the mechanism by which Salmonella typhimurium utilizes T3SS effectors to invade host cells and regulate cell signaling pathways.

Key words： Salmonella typhimurium T3SS Pro-inflammatory effector Anti-inflammatory effector

Received: 15 February 2022 Published: 03 August 2022

ZTFLH:

Q819

Corresponding Authors: Jian-jun QIAO E-mail: jianjunq@tju.edu.cn

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	Chun-xiao YAN
	Hao WU
	Hai-hua RUAN
	Lin YUAN
	Qian-qian SONG
	Jian-jun QIAO

Cite this article:

Chun-xiao YAN,Hao WU,Hai-hua RUAN,Lin YUAN,Qian-qian SONG,Jian-jun QIAO. Research Progress on the Salmonella typhimurium Invading Host Cells. China Biotechnology, 2022, 42(7): 69-78.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2202016 OR https://manu60.magtech.com.cn/biotech/Y2022/V42/I7/69

Fig.1 Needle complex structure of T3SS

Fig.2 The mechanism of pro-inflammatory factors secreted by T3SS

Fig.3 The mechanism of anti-inflammatory factors secreted by T3SS

Table 1 Effectors secreted by Salmonella typhimurium T3SS and their functions


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