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| Research Progress of Antibody Chip Technology and Its Application in Parasite Research |
Jian-da PANG,Yi-ning SONG,Xin-rui WANG,Shu-min SUN( ) |
| College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao 028000,China |
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Abstract With the in-depth development of proteomics related technologies, the study of pathogen invasion and host interaction is becoming more and more in-depth, and the high-throughput and large-scale analysis of protein interaction and protein expression patterns is possible. Through the systematic analysis and identification of proteins, it has a high reference value for the occurrence and development of diseases. Antibody chip analysis of proteins with the advantages of micro-integration, large-scale and high-pass quantification, has been widely used in the field of biomedicine. The current research progress of antibody chip technology and its application in parasite research are reviewed. The development process of parasites has its unique life history, and the expression of parasite proteins and excretory and secretory products at different developmental stages are very different. antibody chip technology is applied to proteomics research of parasites to screen specific marker antigens. It is of great significance to explore the growth and development of parasites, colonization invasion, immune escape and immunosuppression, so as to lay a foundation for the early diagnosis and treatment of parasitic diseases and the search for new drug targets. At the same time, it provides a new idea and method for the further study of parasite proteomics.
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Received: 05 December 2018
Published: 05 August 2019
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Corresponding Authors:
Shu-min SUN
E-mail: shums1975@163.com
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