Please wait a minute...

中国生物工程杂志

China Biotechnology
China Biotechnology  2016, Vol. 36 Issue (9): 81-86    DOI: 10.13523/j.cb.20160910
    
The Research Progress of Flavonoids in Plants
LIU Yi-jie, XUE Yong-chang
School of Biological Engineering, Dalian Polytechnic University, Dalian 116034, China
Download: HTML   PDF(435KB) HTML
Export: BibTeX | EndNote (RIS)      

Abstract  

As a group of compounds which has high medicinal values, flavonoids from plant has been domestic and international hot topics on biology and pharmaceutical research. With the continuous progress of the study, medicinal values and the structure-activity relationships of flavonoids are constantly being discovered, and more and more pharmaceutical formulation of flavonoids have also been put into clinical application. Recent research progress of flavonoids in plant and a systematic elaboration for its species structures, physical and chemical properties, pharmacological activities, separation, purification and identification are summarized, then puts forward corresponding solutions for the problems in the production process and prospects its application in the fields of sanitation and medicine.



Key wordsFlavonoids      Pharmacological activity      Clinical application      Separation and purification     
Received: 04 March 2016      Published: 25 September 2016
ZTFLH:  TQ224  
Cite this article:

LIU Yi-jie, XUE Yong-chang. The Research Progress of Flavonoids in Plants. China Biotechnology, 2016, 36(9): 81-86.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20160910     OR     https://manu60.magtech.com.cn/biotech/Y2016/V36/I9/81

[1] Ma D F, Zhang Y M, Yang T T, et al. Isoflavone intake inhibits the development of 7,12-dimethylbenz(a)anthracene(DMBA)-induced mammary tumors in normal and ovariectomized rats. Journal of Clinical Biochemistry & Nutrition, 2014, 54(1):31-38.
[2] Havsteen B H. The biochemistry and medical significance of the flavonoids. Pharmacology & Therapeutics, 2002, 96(2-3):67-202.
[3] 吴梅姐, 罗彩林, 吴燕珍. 大米草总黄酮的抗菌研究. 世界临床医学, 2015, 9(9):164-165. Wu M J, Luo C L, Wu Y Z. Study on antibacterial flavonoids of rice straw. The World Clinical Medicine, 2015, 9(9):164-165.
[4] Kasala E R, Bodduluru L N, Barua C C, et al. Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Pharmacological Reports Pr, 2016, 68(2):310-318.
[5] 李辉敏, 姜登钊, 殷嫦嫦. 刺头复叶耳蕨总提取物与总黄酮体外抗肿瘤活性的比较研究. 中国现代应用药学, 2015, 32(9):1037-1041. Li H M, Jiang D Z, Yin C C. Comparison of anti-tumor activities of total flavones and extracts from Arachniodes exilis(Hance) Ching in vitro. Chinese Journal of Modern Applied Pharmacy, 2015, 32(9):1037-1041.
[6] Feng R Z, Wang Q, Tong W Z, et al. Extraction and antioxidant activity of flavonoids of Morus nigra. International Journal of Clinical and Experimental Medicine, 2015, 8(12):22328-22336.
[7] 蒙萍, 马慧萍, 王宁, 等. 大苞雪莲总黄酮体外抗氧化活性. 中国实验方剂学杂志, 2015, 21(17):92-95. Meng P, Ma H P, Wang N, et al. Antioxidant activity of total flavonoids of Saussurea involucrate in vitro. Chinese Journal of Experimental Traditional Medical Formulae, 2015, 21(17):92-95.
[8] 卢化, 张义生, 郭胜男,等. 银木总黄酮体外抗氧化活性研究. 中国药师, 2015, 18(4):555-557. Lu H, Zhang Y S, Guo S N, et al. Antioxidant Activity of Total Flavonoids of Cinnamomum septentrionale Hand.-Mzt. China Pharmacist, 2015, 18(4):555-557.
[9] Lu W J, Lin K C, Liu C P, et al. Prevention of arterial thrombosis by nobiletin:in vitro and in vivo studies. Nutritional Biochemistry, 2016, 28(10):1-8.
[10] 耿玮峥, 吕铭洋, 崔新明, 等. 天山花楸叶总黄酮对心肌缺血再灌注损伤大鼠心肌酶和心肌超微结构的影响. 中国实验诊断学, 2015, 19(6):877-879. Geng W Z, Lu M Y, Cui X M, et al. Effect of total flavonoids from Sorbus tianschanica L. leaf for myocardial enzymes and ultrastructure against myocardial ischemia and reperfusion injury in rats. Chinese Journal of Laboratory Diagnosis, 2015, 19(6):877-879.
[11] An J, Yang H, Zhang Q, et al. Natural products for treatment of osteoporosis:the effects and mechanisms on promoting osteoblast-mediated bone formation. Life Sciences, 2016, 147:46-58.
[12] 李洋, 康倩, 荣婵, 等. 骨碎补总黄酮对MLO-Y4细胞增殖、分化、矿化和凋亡影响的探究. 中国骨质疏松杂志, 2015, 21(5):592-598. Li Y, Kang Q, Rong C. Effect of drynaria total flavonoids on the proliferation, differentiation, mineralization, and apoptosis of MLO-Y4 cells. Chinese Journal of Osteoporosis, 2015, 21(5):592-598.
[13] Julkunen-Tiitto R, Nenadis N, Neugart S, et al. Assessing the response of plant flavonoids to UV radiation:an overview of appropriate techniques. Phytochemistry Reviews, 2015, 14(2):273-297.
[14] 张晓娟, 曲新艳, 宋心怡, 等. 阿曼托双黄酮对辐射损伤小鼠骨髓细胞的保护作用. 国际药学研究杂志, 2015,42(3):375-379. Zhang X J, Qu X Y, Song X Y, et al. Protective effect of amentoflavone on radiation-reduced damage in mice bone marrow. Journal of International Pharmaceutical Research, 2015, 42(3):375-379.
[15] 王丽霞, 陈永胜, 穆莎茉莉, 等. 乙醇浸提法提取蓖麻饼粕总黄酮的工艺研究. 食品工业科技, 2015, 36(4):282-285. Wang L X, Chen Y S, Musha M L, et al. Study on the extraction of the total flavonoids from castor bean meal by ethanol extraction technology. Science and Technology of Food Industry, 2015, 36(4):282-285.
[16] 孙琼, 张直峰, 李月梅. 响应面法优化超声辅助提取杏鲍菇黄酮类化合物工艺研究. 食品工业科技, 2015, 36(10):264-268. Sun Q, Zhang Z F, Li Y M. Optimized ultrasonic-assisted extraction process of flavonoids from Pleurotus eryngii by response surface methodology. Science and Technology of Food Industry, 2015, 36(10):264-268.
[17] 李晨晨, 郭惠玲, 俞苓. 两种工艺下蜂胶中活性成分及抗氧化活性的比较. 中国食品添加剂, 2015,9:109-115. Li C C, Guo H L, Yu L. Active components and antioxidant activity of propolis extraction under two kinds of process. China Food Additives, 2015,9:109-115.
[18] 李育峰, 忻龙祚, 张贺. 酶法辅助提取杏仁种皮黄酮的研究. 中国食品添加剂, 2015,11:101-104. Li Y F, Xin L Z, Zhang H. Study on the extraction of flavonoids from almond skin by enzymatic method. China Food Additives, 2015,11:101-104.
[19] 刘海鸥, 虎春艳, 赵声兰,等. 滇黄芩总黄酮酶解超声提取工艺及抗氧化活性研究. 中国酿造, 2016, 35(1):110-114. Liu H O, Hu C Y, Zhao S L, et al. Enzymatic-ultrasonic extraction of total flavonoids from Scutellaria amoena and its antioxidant activities. China Brewing, 2016, 35(1):110-114.
[20] 李继伟, 黄磊, 周云亮,等. 微波辅助水浴提取银杏叶黄酮条件的优化. 食品科技, 2016, 41(1):194-198. Li J W, Huang L, Zhou Y L, et al. Optimization of the extraction conditions of flavonoids from Gingko leaves during microwave-assisted water bath process. Food Science and Technology, 2016, 41(1):194-198.
[21] 李羚, 李丽, 龚赛. 核桃叶黄酮类化合物的双水相与超声耦合提取. 云南化工, 2015, 42(4):19-21. Li L, Li L, Gong S. Extraction of flavonoids by ultrasonic wave and aqueous two-phase system technology from Walnut leaves. Yunnan Chemical Technology, 2015, 42(4):19-21.
[22] 程灏旻, 杨祖全, 唐振洋, 等. 大孔树脂对血橙皮中黄酮类化合物的纯化研究. 广州化工, 2015, 43(4):62-63. Cheng H M, Yang Z Q, Tang Z Y, et al. Purification of flavonoids from blood orange peel by AB-8 macroporous resin. Guangzhou Chemical Industry, 2015, 43(4):62-63.
[23] 孙常磊, 王召平, 孙兆林, 等. 高速逆流色谱分离纯化灯盏细辛中的黄酮类化合物. 山东科学, 2015, 28(3):11-15. Sun C L, Wang Z P, Sun Z L, et al. Separation and purification of flavonoids from Erigeron breviscapus by high-speed counter-current chromatography. Shandong Science, 2015, 28(3):11-15.
[24] 韩伟, 蒋一帅, 魏雨恬. 超滤-纳滤技术在金毛狗脊黄酮分离纯化中的应用. 南京工业大学学报:自然科学版, 2015, 37(1):1-7. Han W, Jiang Y S, Wei Y T. Application of ultrafiltration-nanofiltration technology in purification of flavonoids from Cibotium barometz. Journal of Nanjing University of Technology (Natural Science Edition), 2015, 37(1):1-7.
[25] 李筱玲, 邓寒霜. 黄酮类化合物提取分离方法研究进展. 陕西农业科学, 2015, 61(1):77-79. Li X L, Deng H S. The research progress of extraction and separation method on flavonoids. Shaanxi Journal of Agricultural Sciences, 2015, 61(1):77-79.
[26] 董彩军, 李锋. 黄酮类化合物的研究进展. 农产品加工·学刊, 2010,2:65-69. Dong C J, Li F. The research progress of flavonoids compound. Academic Periodical of Farm Products Processing, 2010,2:65-69.
[27] 张骥, 申鹏, 陆涛, 等. 黄酮类化合物抑制MMP-9的定量结构-活性关系和结构修饰的理论研究. 化学学报, 2011, 69(4):383-392. Zhang J, Shen P, Lu T, et al. Theoretical studies on quantitative structure-activity relationship and structural modification for the inhibition of MMP-9 by flavonoids. Acta Chimica Sinica, 2011, 69(4):383-392.
[28] 黄鑫, 梁剑平, 郝宝成. 黄酮类化合物的分子修饰与构效关系的研究. 安徽农业科学, 2015, 43(11):57-61. Huang X, Liang J P, Hao B C. Study on molecular modification and structure-activity relationship of flavonolds. Journal of Anhui Agricultural Sciences, 2015, 43(11):57-61.

[1] CHEN Xiu-xiu,WU Cheng-lin,ZHOU Li-jun. Research Progress in Preparation and Clinical Application of Therapeutic Human Antibodies[J]. China Biotechnology, 2019, 39(10): 90-96.
[2] Wen-juan CHAI,Qi YANG,Guo-jing LI,Rui-gang WANG. CiMYB15 from Caragana Intermedia Positively Regulates Flavonoids Metabolism of Arabidopsis[J]. China Biotechnology, 2018, 38(10): 8-19.
[3] WU Yi, ZHANG Li-ying, QUAN Chun-shan, ZHONG Mei-ling, WANG Lu-lu, WANG Guan-tian. Synthesis of the ComX Pheromone Precursor Peptide in Bacillus amyloliquefaciens Q-426 Quorum Sensing System[J]. China Biotechnology, 2017, 37(5): 38-44.
[4] XIE Xi-zhen, LIN Juan, XIE Yong, YE Xiu-yun. Separation and Purification of Agarase and Study on Its Properties[J]. China Biotechnology, 2017, 37(1): 46-52.
[5] WANG Dian-liang, DU Juan. The Current Research and Development Status of Cell Drug[J]. China Biotechnology, 2016, 36(9): 126-133.
[6] HAN Han, BAO Dan-qi, YANG Fei-yun, LIU Kun, YANG Tian-rui, YANG Qi, LI Guo-jing, WANG Rui-gang. The Cloning and Function Analysis in Flavonoid Pathway of CiCHIL from Caragana intermedia[J]. China Biotechnology, 2016, 36(9): 11-20.
[7] WANG Dian-liang. The Clinical Application of Cell Drug[J]. China Biotechnology, 2016, 36(12): 117-123.
[8] TANG Wen-yan, LUAN Zuo. Biological Characteristics and Clinical Application of Endothelial Progenitor Cells[J]. China Biotechnology, 2016, 36(10): 86-93.
[9] WANG Kai, ZHANG Wei, LI Shi-weng. Study and Application of Phytase[J]. China Biotechnology, 2015, 35(9): 85-93.
[10] FENG Cui, WANG Qi, ZHANG Chun, QIN Pei-yong, ZHANG Xiu-yu, WANG Jian, LIU Yong-dong, SU Zhi-guo. Preparation of mPEG-MAL-modified Recombinant Human Ciliary Neurotrophic Factor and Evaluation of Biological Activity[J]. China Biotechnology, 2015, 35(5): 15-21.
[11] ZHANG Qiao-Juan, ZHANG Yan-Qiong, LIU Chang-Bai. TALEN:A New Genome Site-specific Editing Technology[J]. China Biotechnology, 2014, 34(7): 76-80.
[12] ZHAO Ying, LIU Jin, WANG Chang-song, ZHAO Guang-rong. Advances on Flavonoids Production of Engineered Microorganisms[J]. China Biotechnology, 2014, 34(4): 110-117.
[13] WANG Dian-liang. Clinical Researches of Tissue Engineering[J]. China Biotechnology, 2014, 34(10): 114-120.
[14] FENG Cui, ZHAO Da-wei, ZHANG Chun, WANG Jian, QIN Pei-yong, LIU Yong-dong, SU Zhi-guo. Purification and Characterization of a New Recombinant Cilinary Neuronotrophic Factor Mutant Expressed in Soluble Form by E.coli[J]. China Biotechnology, 2013, 33(10): 21-27.
[15] MIAO Liang, XU Li-hua, JI Xu, BIAN Liu-jiao. Cloning, Expression, Purification and its Biological Activity Study of the Soluble Tripolymer Recombinant Angiogenesis Inhibitor Kringle 5[J]. China Biotechnology, 2011, 31(03): 18-22.