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中国生物工程杂志

China Biotechnology
China Biotechnology  2015, Vol. 35 Issue (9): 78-84    DOI: 10.13523/j.cb.20150912
    
Design of Mdm2/MdmX Inhibitors
QIN Ling-yun, CHEN Rong, SU Zheng-ding
Department of Biotechnology, Hubei Collaborative Innovation Center for Industrial Fermentation, Key Laboratory of Industrial Fermentation of Ministry of Education, Hubei University of Technology, Wuhan 430068, China
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Abstract  

Inhibition of p53 by abnormaloverexpression of Mdm2 (murine double minute 2, also known as Hdm2) and MdmX (murine double minute X, also known as Hdm4) is relevant to nearly half of cancers. Thereby it is clinically profound that the removal of the inhibition of Mdm2/MdmX to p53 by designing Mdm2/MdmX-specific inhibitors. Structurally Mdm2 and MdmX are similar to each other, but the discovery of Mdm2 inhibitor has so far made advanced progress compared to the design of MdmX inhibitors. The progress on the design of MdmX inhibitors based on the structure-activity relationships of nutlins (Mdm2 inhibitors), structural biology and combinatorial chemistry were reviewed. The potential application of natural compounds is discussed for searching novel scaffolds of Mdm2/MdmX inhibitors.



Key wordsp53      MdmX inhibitors      Drug design      Natural compounds     
Received: 22 April 2015      Published: 25 September 2015
ZTFLH:  Q816  
Cite this article:

QIN Ling-yun, CHEN Rong, SU Zheng-ding. Design of Mdm2/MdmX Inhibitors. China Biotechnology, 2015, 35(9): 78-84.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20150912     OR     https://manu60.magtech.com.cn/biotech/Y2015/V35/I9/78


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