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中国生物工程杂志

China Biotechnology
China Biotechnology  2015, Vol. 35 Issue (8): 96-102    DOI: 10.13523/j.cb.20150814
    
Research Progress on in vitro Models of HIV-1 Latency
KANG Xue-jun, YANG Yi-shu
College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, China
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Abstract  

Latent infection in resting memory CD4+ T cells is the major barrier to HIV-1 eradication. Under most circumstances, proviral cDNA was integrated into the host genome. Due to the factors from virus or the host, the transcription was interrupted, without producing any detected viral proteins. So the latently infected cells could not suffer the cytopathic effect from the virus, the attack from cytotoxic T lymphocyte, or the antiviral effect from the anti-retroviral therapy. It is urgent to decrease the latent reservoir in AIDS treatment. In vivo or in vitro latency models are beneficial for further studying the mechanism of latency establishment, maintenance or reactivation. The focuses are mainly on the in vitro HIV-1 latency models using immortalized cell lines, primary resting CD4+ T cells or activated CD4+ T cells.



Key wordsHuman immunodeficiency virus type 1      Latent infection      Reactivation      in vitro model     
Received: 10 April 2015      Published: 25 August 2015
ZTFLH:  Q819  
Cite this article:

KANG Xue-jun, YANG Yi-shu . Research Progress on in vitro Models of HIV-1 Latency. China Biotechnology, 2015, 35(8): 96-102.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20150814     OR     https://manu60.magtech.com.cn/biotech/Y2015/V35/I8/96


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