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Advances in Stem Cell 3D Scaffolds |
XU Zhu, ZHUGE Qi-chuan, HUANG Li-jie |
Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China |
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Abstract Stem cells are characterized by the capacity of self-renewing and umlimited proliferation and differentiation. They can differentiate into specialized cells under different culture or induced conditions. At present, with the development of medical treatment and stem cell research, it is found that stem cells can be used for the treatment of many diseases. The clinical application of stem cells is in a vast need. However, stem cell transplantation efficiency is very low in vivo. It is still need to figure out the method of stem cells expansion, stable proliferation and differentiation. Currently,the main culture method of the stem cells is still 2D culture. 2D culture can not simulate the 3D microenvironment in the body, and the reproductive efficiency is low. There are emerging results to overcome the limition of 2D culture method by the experts. Here the development and application of 3D culture technologies of stem cells were reviewed.
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Received: 26 November 2016
Published: 25 September 2017
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