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中国生物工程杂志

China Biotechnology
China Biotechnology
China Biotechnology  2015, Vol. 35 Issue (9): 105-113    DOI: 10.13523/j.cb.20150915
    
The Effect of Inorganic Phosphate on the Biosynthesis of Secondary Metabolites in Streptomyces
YIN Shou-liang1,2, ZHANG Yu-xiu1, ZHANG Qi1, DOU Meng-nan1, YANG Ke-qian2
1 Department of Environmental and Biological Engineering, School of Chemical and Environmental Engineering, China University of Mining and Technology, Beijing 100083, China;
2 State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
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Abstract  

Streptomyces are well known as a particularly abundant source of secondary metabolites, including antibiotics, immunosuppressants, anti-cancer agents and many other bioactive compounds. Many of them have important application in the field of clinical medicine and aquaculture, etc. Nevertheless, the synthesis of secondary metabolites is often closely related with environmental and nutritional factors. Herein,the influence of inorganic phosphate and the molecular mechanism of the two-component PhoR-PhoP signal transduction system on the synthesis of secondary metabolites are reviewed. Streptomycetes sense and respond to phosphate via the two-component PhoR-PhoP signal transduction system.When the concentration of phosphate in the environments decreases below a threshold level. PhoP plays a major role in the repression of the central and secondary metabolic pathways to slow down the consumption of phosphate, and the activation of scavenging uptake and transport systems that allow the cell to recover inorganic phosphate from external sources, which ultimately affect the secondary metabolites production and morphological differentiation.

Key words： Secondary metabolites      Inorganic phosphate      The two-component PhoR-PhoP signal transduction system      Molecular mechanism     
Received: 14 April 2015      Published: 25 September 2015
ZTFLH:  Q582  
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Cite this article:

YIN Shou-liang, ZHANG Yu-xiu, ZHANG Qi, DOU Meng-nan, YANG Ke-qian. The Effect of Inorganic Phosphate on the Biosynthesis of Secondary Metabolites in Streptomyces. China Biotechnology, 2015, 35(9): 105-113.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20150915     OR     https://manu60.magtech.com.cn/biotech/Y2015/V35/I9/105


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